Thursday, July 27, 2017

Frontotemporal dementia pick's disease

What are frontotemporal disorders? What is the progression of frontal lobe dementia? The other two frontotemporal dementias are semantic dementia and primary progressive aphasia. Frontotemporal dementia often begins between the ages of and 65.


All three dementias have some genetic causes , for they often run in families. The disease often affects a person’s ability to use and understand spoken and written language.

This page explains what FTD is, its symptoms , and who gets it. It also describes how it is diagnosed and the treatment and support that is available. Find out about frontotemporal dementia and what causes it.


It encompasses a group of disorders that affect behavior, emotions, communication and cognition. These are the areas responsible for our behaviour, our emotional responses and our language skills. This disease is one of many types of dementias known as frontotemporal dementia (FTD).


If you have dementia, your brain doesn’t function normally. Pick’s disease is a rare condition that causes progressive and irreversible dementia.

It affects parts of the brain that control emotions, behavior, personality, and language. In contrast to Alzheimer’s disease, memory often remains unaffected in FT. The symptoms of FTD depend on which areas of the brain are damaged. The disease typically begins with two broad groups of symptoms: (1) progressive changes in behavior, or (2) progressive problems with language.


Antipsychotic medications, such as olanzapine (Zyprexa) or quetiapine (Seroquel), are sometimes used to combat the behavioral problems of frontotemporal dementia. However, these medications must be used with caution because the side effects include an increased risk of death in dementia patients. This is the third most common cause of dementia , after Alzheimer’s disease and diffuse Lewy-body dementia (excluding dementia caused by strokes ). Pick disease is characterized by the presence of Pick bodies, which are tangles of abnormal nerve cell proteins called tau proteins. MSnapshot: A 59-year-old male is brought to the physician by his wife due to odd behavior. She reports that he would attempt to kiss strangers, or would urinate in public.


It may be the most common kind of dementia. But there are other types that are less well-known. Symptoms of frontotemporal dementia include changes in behavior or problems with language.


FTD brings progressive changes to personality, language, decisonmaking, behavior, and movement. The clinical presentation in frontotemporal dementia (FTD) reflects the distribution of the pathologic changes rather than the exact histologic subtype of the disease. Three major clinical syndromes can be identified: 1) frontal variant FTD ( dementia of frontal type) in which changes in social behavior and personality predominate, reflecting the orbitobasal frontal lobe focus of the pathology. The frontotemporal dementias encompass six types of dementia involving the frontal or temporal lobes.


They are: behavioral variant of FT semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.

The term Pick complex was also suggested for the whole syndrome including frontotemporal dementia , primary progressive aphasia, and corticobasal degeneration and the spectrum of underlying pathologic features, so that frontotemporal dementia can be used for the behavioral presentation only. FTD is a progressive disorder of the brain.

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